Relationships between insulin resistance and frailty with body composition and testosterone in men undergoing androgen deprivation therapy for prostate cancer

AS Cheung; R Hoermann; P Dupuis; DL Joon; JD Zajac; M Grossmann

Journal article

Relationships between insulin resistance and frailty with body composition and testosterone in men undergoing androgen deprivation therapy for prostate cancer

AS Cheung, R Hoermann, P Dupuis, DL Joon, JD Zajac, M Grossmann

European Journal of Endocrinology | OXFORD UNIV PRESS | Published : 2016

DOI: 10.1530/EJE-16-0200

Abstract

Objective: While androgen deprivation therapy (ADT) has been associated with insulin resistance and frailty, controlled prospective studies are lacking. We aimed to examine the relationships between insulin resistance and frailty with body composition and testosterone. Design: Case-control prospective study. Methods: Sixty three men with non-metastatic prostate cancer newly commencing ADT (n = 34) and age-matched prostate cancer controls (n = 29) were recruited. The main outcomes were insulin resistance (HOMA2-IR), Fried's frailty score, body composition by dual x-ray absorptiometry and short physical performance battery (SPPB) measured at 0, 6 and 12 months. A generalised linear model deter..

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University of Melbourne Researchers

Ada Cheung Author

Jeffrey Zajac Author

Mathis Grossmann Author

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Grants

Awarded by National Health and Medical Research Council

Funding Acknowledgements

The study was funded by a National Health and Medical Research Council (NHMRC) of Australia Project Grant (#1006407). Ada Cheung is supported by a NHMRC Medical and Dental Postgraduate Research Scholarship (#1017233) to undertake this project as part of PhD studies. Mathis Grossmann is supported by a NHMRC Career Development Fellowship (#1024139).